Duszynski Lab

As the focal site of oxidative metabolism, mitochondria are the powerhouse of the cell. They are involved not only in ATP production and various metabolic pathways but also in many signaling cascades. Moreover, they are the main site of reactive oxygen species (ROS) generation within the cell. The central role of mitochondria in many physiological processes, for example: apoptosis, ageing, division, mobility etc. is well documented now.

In the laboratory of Bioenergetics and Biomembranes we investigate metabolism, structure, function and dynamics of mitochondria, both under physiological and pathological conditions. Our main research interests are focused on normal physiology of mitochondria as well as on effects of mitochondrial defects on cell structure, energy state of the cell, generation of reactive oxygen species and cellular calcium homeostasis. We study various experimental models: various cell lines, cells derived from patients with metabolic disorders or glycogen storage disease. Our laboratory has also a long-standing interest in the role of p66Shc protein in oxidative stress and ageing.


New manuscript accepted for publication

2018-03-09 16:16:16

We are pleased to announce that the manuscript by: 

Carlotta Giorgi*, Saverio Marchi*, Ines C.M. Simoes*, Ziyu Ren*, Giampaolo Morciano*, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Szabadkai, Barbara Zavan, Paulo J. Oliveira, Vilma A. Sardao, Paolo Pinton and Mariusz R. Wieckowski (2018) "MITOCHONDRIA AND REACTIVE OXYGEN SPECIES IN AGING AND AGE-RELATED DISEASES"

has been accepted for publication in International Review of Cell and Molecular Biology