Duszynski Lab

As the focal site of oxidative metabolism, mitochondria are the powerhouse of the cell. They are involved not only in ATP production and various metabolic pathways but also in many signaling cascades. Moreover, they are the main site of reactive oxygen species (ROS) generation within the cell. The central role of mitochondria in many physiological processes, for example: apoptosis, ageing, division, mobility etc. is well documented now.

In the laboratory of Bioenergetics and Biomembranes we investigate metabolism, structure, function and dynamics of mitochondria, both under physiological and pathological conditions. Our main research interests are focused on normal physiology of mitochondria as well as on effects of mitochondrial defects on cell structure, energy state of the cell, generation of reactive oxygen species and cellular calcium homeostasis. We study various experimental models: various cell lines, cells derived from patients with metabolic disorders or glycogen storage disease. Our laboratory has also a long-standing interest in the role of p66Shc protein in oxidative stress and ageing.


New manuscripts accepted

2016-06-28 18:47:00

We are pleased to announce, that recently three our manuscripts:


1) Monika Oparka*, Jarosław Walczak*, Dominika Malinska*, Lisanne M.P.E. van Oppen*, Joanna Szczepanowska, Werner J.H. Koopman and Mariusz R. Wieckowski (2016) Quantifying ROS levels using CM-H2DCFDA and HyPer” Methods Jun 11. pii: S1046-2023(16)30172-4


2) Patergnani S , Fossati V , Bonora M, Giorgi C, Marchi S , Missiroli S, Rusielewicz T, Wieckowski MR, Pinton P (2016) Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis. Int Rev Cell Mol Biol – in press


3) Alessandro Rimessi, Maurizio Previati, Federica Nigro, Mariusz R. Wieckowski and Paolo Pinto Mitochondrial Reactive Oxigen Species and inflammation: molecular mechanisms, diseases and promising therapies. The International Journal of Biochemistry and Cell Biology - in press


have been accepted for publication.