Duszynski Lab

As the focal site of oxidative metabolism, mitochondria are the powerhouse of the cell. They are involved not only in ATP production and various metabolic pathways but also in many signaling cascades. Moreover, they are the main site of reactive oxygen species (ROS) generation within the cell. The central role of mitochondria in many physiological processes, for example: apoptosis, ageing, division, mobility etc. is well documented now.

In the laboratory of Bioenergetics and Biomembranes we investigate metabolism, structure, function and dynamics of mitochondria, both under physiological and pathological conditions. Our main research interests are focused on normal physiology of mitochondria as well as on effects of mitochondrial defects on cell structure, energy state of the cell, generation of reactive oxygen species and cellular calcium homeostasis. We study various experimental models: various cell lines, cells derived from patients with metabolic disorders or glycogen storage disease. Our laboratory has also a long-standing interest in the role of p66Shc protein in oxidative stress and ageing.


News

New manuscripts accepted for publication

2018-08-12 15:20:20

We are pleased to announce that recently four our manuscripts have been accepted for publication:

 

Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P. (2018) Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction. Journal of Medicinal Chemistry  - in press

 

 

Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P and Galluzzi L (2018) "Targeting mitochondria for cardiovascular disorders: therapeutic potential and persisting obstacles" Nature Reviews Cardiology - in press

 

 

Claudia Morganti, Sonia Missiroli, Magdalena Lebiedzinska-Arciszewska, Letizia Ferroni, Lucia Morganti, Mariasole Perrone, Daniela Ramaccini, Savino Occhionorelli, Barbara Zavan, Mariusz R. Wieckowski and Carlotta Giorgi (2018) Regulation of PKCβ levels and autophagy by PML is essential for high glucose-dependent mesenchymal stem cells adipogenesis. International Journal of Obesity - in press

 

 

Paulina Jędrak, Paweł Mozolewski, Grzegorz Węgrzyn and Mariusz R. Więckowski (2018) "Mitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington's disease patients" Metabolic Brain Disease - in press